¿Qué es Baicalin 85% Scutellaria baicalensis Root Extract - Pienso Phytogenic / Natural Antioxidant? Aplicaciones, dosis, alternativas y especificaciones

Baicalin, also known as Baicalein 7-O-glucuronide, es un flavonoid compound extractoed and isolated from the dried root of Scutellaria baicalensis Georgi, a plant of the Lamiaceae family. Its molecular formula is C21H18O11 and its molecular weight is 446.36. The CAS number is 21967–41–9. Scutellaria baicalensis es un traditional Chinese medicinal herb, first recorded in the Shennong Bencao Jing (Divine Farmer's Materia Medica), con una long history of clinical application. As the main active component of Scutellaria baicalensis, baicalin exhibits multiple pharmacological effects incluyendo anti-inflammatory, antibacterial, antiviral, antipyretic, antihypertensive, choleretic, and diuretic activities. Baicalin exists primarily in the form of a glycoside in nature, and its aglycone is baicalein.

Physical Properties: Baicalin appears as amarillo claro to yellow cristalline polvo, odorless, con un extremely bitter taste. Its punto de fusión is 223–225°C (decomposition). It is soluble en baceiteing ethanol, slightly soluble en methanol or ethanol, very slightly soluble en chloroform, and insoluble en agua or ether. It is soluble en alkaline solucións como sodium bicarbonate, sodium carbonate, and sodium hydroxide, but is unstable in alkaline solucións, gradually turning dark brown. The specific optical rotation [α]18D is +123° (c=0.2, pyridine-water).

As a flavonoid compound, baicalin exerts its pharmacological activities primarily through the following mechanisms: 1 Anti-inflammatory Effect: Baicalin exerts broad-spectrum anti-inflammatory effects by inhibiting NF-κB activation, reducing the release of pro-inflammatory cytokines (como TNF-α, IL-6, IL-1β), and suppressing COX-2 expression. 2 Antioxidant Effect: Baicalin exhibits significant superoxide anion radical scavenging activity, ranking among the top flavonoid compounds in O2− scavenging capacity. It protege cells from oxidative damage through direct free radical scavenging and mejoranment of endogenous antioxidante enzima activities. 3 Antibacterial and Antiviral Effects: Baicalin exhibits inhibitory effects against various Gram-positive and Gram-negative bacteria, así como antiviral activity against influenza virus, respiratory syncytial virus, y otross. 4 Hepatoprotegenive Effect: Baicalin protege against chemical-induced liver injury, alcoholic liver disease, and non-alcoholic fatty liver disease through antioxidante, anti-inflammatory, and anti-apoptotic mechanisms. 5 Neuroprotegenive Effect: Baicalin can cross the blood-brain barrier and exert neuroprotegenive effects in neurodegenerative diseases como Alzheimer's disease and Parkinson's disease.