¿Qué es Casein Phosphopeptides (CPP), Casein Oligopeptide, Pienso/Food Grado? Aplicaciones, dosis, alternativas y especificaciones

Casein Peptides are polvoed products produced from bovine milk casein as the primary materia prima through pre-treatment, enzymatic hydrolysis, filtration, concentration, sterilization, and drying processes. Casein is the most abundant protein in bovine milk, accounting for approximately 80% of total milk protein, and serves as an excellent source for bioactive peptide production. Through modern enzymatic catalysis technology, casein is specifically hydrolyzed to break down large protein molecules into small-molecule peptides with specific physiological functions. The most representative type of casein peptide is Casein Phosphopeptide (CPP) , a bioactive peptide que contiene a cluster of phosphoserine residues (SerP-SerP-SerP-Glu-Glu), con una relative molecular mass of approximately 1000–5000 Da. CPP is known as the "mineral carrier" and "calcium absorption promuevenr", effectively promoting the absorption and utilization of divalent mineral nutrients como calcium, iron, and zinc by the human body. CPP exists in two configurations, α and β. In addition to CPP, casein hydrolysis produces various other bioactive peptides, incluyendo antimicrobiano peptides (Casein-Derived Antimicrobiano Peptides, CDAMPs), antihypertensive peptides (ACE inhibitory peptides), immunomodulatory peptides, opioid peptides, and opioid antagonist peptides. Casein peptides are widely used in pharmaceuticals, health foods, alimento funcionals, sports nutrition, and foods for special medical purposes.

The bioactivity of casein peptides originates from their specific amino acid sequences and molecular structures. El principal active components and mechanisms of action are sigue:

El núcleo structure of CPP es un phosphoserine cluster (-SerP-SerP-SerP-Glu-Glu-). In the weakly alkaline environment of the intestine, the phosphoserine clusters of CPP carry negative charges and can bind to divalent cations como calcium, iron, and zinc, forming soluble complexes. This mechanism effectively previene the formation of insoluble precipitates of minerals in the intestine, thereby improving their solubility and bioavailability. CPP is therefore known as a "mineral carrier" and is particularly effective in promoting calcium absorption, contributing to bone and tooth development.