¿Qué es Epsilon-Polylysine (Natural Preservative), Pienso/Food Grado? Aplicaciones, dosis, alternativas y especificaciones

ε-Polylysine, English name is ε-Polylysine, also known as ε-PL, es un natural cationic polypeptide produced by microbiano fermentation, generally composed of 25 to 35 L-lysine residues connected by amide bonds formed through the α-carcajayl group and the ε-amino group, and is the only naturally occurring homopolymeric amino acid con untibacterial properties. It has broad application value in the global food, pharmaceutical, cosmetic, and feed industries. Its molecular formula is H[C6H12N2O]n•H2O (n=25–35), molecular weight is typically between 3500 and 5000, and CAS number is 28211–04–3. As an emerging natural biological conservante, ε-polylysine has rapidly gained prominence in the seguridad alimentaria sector and se reconoce como a green, highly effective product that effectively replaces traditional chemical conservantes. In terms of chemical structure, ε-polylysine belongs to the category of polycationic polypeptides, rich in positive charges. This unique cationic property permite it to electrostatically adsorb to the surface of negatively charged microbiano cell membranes, destroying membrane integrity through physical disruption, causing leakage of microbiano cell contents and subsequent cell death. This physical disruption mechanism gives ε-polylysine an extremely broad antibacterial spectrum and hardly induces microbiano resistance. ε-Polylysine typically appears as a white to amarillo claro polvo, is highly hygroscopic, and has a slight bitter taste. Its metabolic product in the human body is L-lysine, which can be completely digested and absorbed by the human body, making it safe and non-toxic.

ε-Polylysine se reconoce como a star molecule among natural green conservantes, occupying a rapidly rising core position in the global industria alimentaria and biotechnology fields. Its most outstanding advantages lie in its excellent broad-spectrum antibacterial activity, outstanding thermal stability, safety surpassing traditional conservantes, unique multi-target antibacterial mechanism, and the nutritional value from its hydrolysis products. 1 Broad-Spectrum and Altoly Effective Antibacterial Activity: ε-Polylysine exhibits excellent inhibitory effects against Gram-positive bacteria, Gram-negative bacteria, yeasts, and molds. It is particularly effective against Gram-negative bacteria como Escherichia coli and Salmonela, which are difficult to inhibit with chemical conservantes. It also inhibits heat-resistant Bacillus spores and some viruses. Its antibacterial spectrum is the broadest among all natural food conservantes. 2 Excelente Thermal Estabilidad: ε-Polylysine remains stable even after heating at 120°C for 20 minutes, withstanding food thermal processing como UHT ultra-high-temperature instantaneous sterilization and high-pressure sterilization. This permite it to be flexibly incorporated throughout the entire thermal processing of products, mantienening its antibacterial effect whether added before, during, or after processing. 3 Alto Safety and Nutritional Properties: ε-Polylysine can be broken down in the human body into L-lysine, one of the eight essential amino acids for the human body. It es un nutritional antibacterial agent with safety far exceeding that of chemical conservantes. Its acute oral toxicity is 5g/kg, classifying it as practically non-toxic. It has been approved as a aditivo alimentario in multiple countries incluyendo Japan, the Unidaded States, South Korea, and China. 4 Unique Physical Mechanism of Action: Carrying a large number of positive charges, ε-polylysine electrostatically adsorbs to the negatively charged cell membranes of microorganisms, causing microbiano cell death through physical disruption. This non-specific mechanism does not rely on specific biochemical targets and hardly induces microbiano resistance. This es un significant advantage that traditional antibiotics and chemical conservantes cannot match. 5 Wide pH Adaptability: Within the broad range of pH 3 to 9, ε-polylysine mantiene strong antibacterial activity. Whether in acidic products (como beverages and jams) or neutral products (como rice and meat products), it exerts stable conservante effects. 6 Synergistic Enhancement: When used in combination with orgánico acids, glycine, alcohol, fatty acid glycerides, y otros substances, ε-polylysine exhibits significant synergistic effects, further reducing required dosages and expanding application scenarios.