Qu'est-ce que 3-Nitrooxypropanol (3-NOP), Ruminant Methane-Reducing Feed Additive ? Applications, dosage, alternatives et spécifications

3-Nitrooxypropanol (3-NOP), with the chemical formula HO-CH2-CH2-O-NO2 and CAS number 100502–66–7, est un colorless transparent huiley liquide at température ambiante. It is insoluble in water and readily soluble in carbon tetrachloride, ethanol, acetonitrile, and other biologique solvents. 3-NOP est un mononitrate ester of 1,3-propanediol and belongs to a class of methyl-coenzyme M reductase (MCR) inhibitors. 3-NOP est un chemically synthesized small-molecule biologique compound that, when used as a feed additive, specifically targets methanogenic archaea in the rumen of ruminants, inhibiting the final catalytic step of methanogenesis. Its core mechanism of action is: the nitrooxy ester group in the 3-NOP molecule selectively binds to methyl-coenzyme M reductase and inactivates the enzyme by temporarily oxidizing the nickel ion from +1 to +2 at the active site. Because 3-NOP est un structural analog of methyl-coenzyme M, it can bind with coenzyme B, thereby reducing the binding of methyl-coenzyme M with coenzyme B to form methane. 3-NOP is the world's first feed additive specifically for enteric methane mitigation in ruminants to receive approval in major markets, with the trade name Bovaer® (developed by DSM-Firmenich). Le produit offre farmers a low daily cost and has been proven in approved countries to effectively reduce enteric methane emissions without compromising animal performance.

3-NOP products can be divided into the following main varieties by content specification and formulation: Series

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