Qu'est-ce que Fumonisin-Degrading Enzyme (FumD Carboxylesterase / Fumzyme), Feed Mycotoxin Detoxifier ? Applications, dosage, alternatives et spécifications

Fumonisin Degrading enzyme est un class of bio-enzyme preparations that can specifically convert fumonisins (FUM) in feed and food into low-toxicity or non-toxic products. Fumonisins are water-soluble secondary metabolites produced by Fusarium fungi such as Fusarium verticillioides and Fusarium proliferatum. To date, 28 fumonisin analogues have been identified, classified into four series: A, B, C, and P, among which FB1 is the most widespread and toxic contaminant. Fumonisin Degrading enzymes primarily belong to the esterase class (EC 3.1.1.87). Their mechanism of action involves a two-step enzymatic reaction for complete detoxification of fumonisins: first, under the action of carboxylesterase, fumonisin B1 (FB1) is degraded to hydrolyzed fumonisin B1 (HFB1), with significantly reduced toxicity; subsequently, under the action of aminotransferase, HFB1 undergoes transamination to ultimately convert to 2-keto-HFB1. This synergistic "esterase + aminotransferase" mechanism garantit complete degradation of fumonisins into non-toxic metabolites. Fumonisins are the second most prevalent group of mycotoxins worldwide. Since 2014, fumonisins have been detected in 50% to 80% of États-Unis corn samples. Monitoring data from 2025 shows that fumonisin detection rates in Chine and Taiwan reached 99%, exceeding risk thresholds. As a feed additive, the core function of Fumonisin Degrading enzyme is to degrade fumonisins in the animal digestive tract into non-toxic products, protecting animal health. The world's first commercial fumonisin degrading enzyme product is FUMzyme® (developed by BIOMIN, a DSM-Firmenich company), which is the first FDA-approved purified enzyme to specifically and irreversibly degrade fumonisins into non-toxic metabolites. This product has received regulatory approvals from major markets including the UE, États-Unis FDA, and Canadian CFIA.

Fumonisin Degrading enzyme can be divided into the following main varieties by enzyme source, mechanism of action, and application field: Series

Fumonisin Degrading enzyme occupies a unique position in the global mycotoxin detoxifier market characterized by "specificity, efficiency, irreversibility, and no secondary pollution." Its core advantages include: