Antimicrobial Peptides (AMPs), Green Antibiotic Alternativeとは？用途・使用量・代替品・規格

Feed Grade Antimicrobial Peptides (AMPs) are a class of alkaline polypeptide substances produced by animals, plants, or microorganisms, and are important components of the innate immune system. Antimicrobial peptides typically consist of 20–60 amino acid residues, with molecular weights ranging from 2,000 to 7,000 Da, and are characterized by strong alkalinity, good thermal stability, and a broad antimicrobial spectrum. The mechanism of action of antimicrobial peptides is fundamentally different from that of antibiotics. Antibiotics typically act through single targets such as inhibiting bacterial cell wall synthesis, protein synthesis, or nucleic acid replication. In contrast, antimicrobial peptides are first attracted to the bacterial cell membrane surface through electrostatic interactions, then their hydrophobic tails insert into the hydrophobic regions of the cell membrane, altering membrane conformation. Multiple antimicrobial peptides on the cell membrane to form ion channels, causing leakage of bacterial cell contents and rapid bacterial cell death. This unique bactericidal mechanism, which physically disrupts the cell membrane, makes it difficult for bacteria to develop resistance. Feed Grade Antimicrobial Peptides (Industrial Specialized Strain System) are standardized, large-scale antimicrobial peptide products produced through high-density fermentation of specific industrial strains (such as Pichia pastoris engineered strains, Bacillus subtilis, etc.) using modern bioengineering technology. They possess core characteristics including broad-spectrum antimicrobial activity, no resistance development, no residues, and digestibility by animals, making them an ideal green additive for replacing feed antibiotics.

Feed Grade Antimicrobial Peptides can be divided into the following main varieties by source, structure, and production process: Series

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