Milk Thistle Extract (Silymarin/Silybin)とは？用途・使用量・代替品・規格

Milk Thistle, with botanical name Silybum marianum (L.) Gaertn., is an annual or biennial herb belonging to the Asteraceae family. Milk Thistle Extract (also known as Silymarin) is a natural plant extract produced from the dried ripe fruits of Silybum marianum through extraction, purification, and drying processes. The main active component is Silymarin, which appears as a yellow or brown-yellow powder or crystalline powder with a bitter taste. Silymarin has been used to treat hepatobiliary diseases for over 2,000 years. In ancient Greece and Roman times, Milk Thistle was already used to treat liver and gallbladder disorders. Modern research shows that Silymarin is recognized as one of the most effective flavonoids for liver diseases discovered to date, earning the title of "natural hepatoprotective agent". Silymarin refers to a flavonolignan compound extracted from the seed coat of Silybum marianum, a medicinal plant of the Asteraceae family [10†L5-L6]. Silymarin exhibits multiple pharmacological activities and is widely used in pharmaceuticals, health foods, foods, and cosmetics.

The core active component of Milk Thistle Extract is Silymarin, a flavonolignan compound complex primarily consisting of four isomers: Silybin (also called Silibinin), Isosilybin, Silychristin, and Silydianin. Silybin is the most abundant and biologically active component in Silymarin, typically accounting for 50% to 70% of total Silymarin content. Active Component

(3) Promotion of Hepatocyte Regeneration and Repair: Silymarin accelerates DNA synthesis in liver cells and promotes protein synthesis, facilitating the production of new hepatocytes or the repair of already damaged ones. Clinical studies have demonstrated that Silybin stabilizes the hepatocyte membrane, maintains its integrity, promotes the restoration of hepatocellular ultrastructure, enhances the division and growth of normal hepatocytes, and increases the synthesis of RNA and proteins in hepatocytes.