What Is Neotame (and Neotame Syrup Form)? Applications, Dosage, Alternatives & Specifications

Neotame, chemically named N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester, is a non-nutritive high-intensity sweetener derived from aspartame by structural modification, belonging to the dipeptide intense sweetener category. Its molecular formula is C20H30N2O5, molecular weight is 378.46, CAS number is 165450–17–9, CNS number is 19.019, and INS number is 961. Neotame appears as white crystalline powder containing about 4.5% water of crystallization. It has a pure sweet taste that is harmonious and very close to aspartame, without the bitter or metallic aftertaste commonly found in other intense sweeteners. Its sweetness is 7,000 to 13,000 times that of sucrose, and 30 to 60 times that of aspartame, making it one of the highest-intensity artificial sweeteners in the world. Its energy value is nearly zero, making it a functional sweetener. Neotame remains stable under instantaneous high-temperature conditions. After 450°C high-temperature baking in cake production, 85% of neotame still remains. Under acidic conditions, neotame has approximately the same stability as aspartame. Under neutral pH conditions or instantaneous high-temperature conditions, neotame is much more stable than aspartame, greatly expanding its application areas. Neotame is widely used in the food industry, pharmaceutical industry, and daily chemical industry. In the food industry, it can be used in beverages, baked goods, confectionery, chewing gum, dairy products, canned foods, jellies, jams and other products. In the pharmaceutical field, it is used as a sweetener and flavor masking agent in oral preparations, chewable tablets, syrups and other pharmaceuticals. In the daily chemical industry, it is used in toothpaste and cosmetics. Neotame has no restrictions on applicable populations, being suitable not only for individuals including those with obesity, diabetes and cardiovascular disease, but also for phenylketonuria (PKU) patients who cannot use aspartame.

Appearance: White crystalline powder containing about 4.5% water of crystallization.

Molecular Formula and Molecular Weight: C20H30N2O5, molecular weight 378.46.