What Is Micronized trans-Resveratrol? Applications, Dosage, Alternatives & Specifications

Resveratrol, chemically known as 3,5,4'-trihydroxystilbene, has the molecular formula C14H12O3 and CAS number 501–36–0. Resveratrol is a naturally occurring non-flavonoid phenolic compound belonging to the stilbene class. It is a phytoalexin – a defensive substance produced by plants in response to pathogen attack (such as bacteria or fungi) or injury. Resveratrol exists in both free forms (cis, trans) and glycoside-bound forms (cis, trans), all of which possess antioxidant activity. Its natural sources are widely distributed across various plants including grapes, blueberries, raspberries, mulberries, peanuts, and Polygonum cuspidatum. Among these, trans-resveratrol is the most common and biologically active isomer found in nature. Resveratrol appears as a white to off-white crystalline powder, odorless, poorly soluble in water, and readily soluble in ethanol, acetone, and other organic solvents. It exhibits multiple bioactivities including antioxidant, anti-inflammatory, anti-aging, anti-cancer, and cardiovascular disease prevention. Resveratrol is widely applied in dietary supplements, pharmaceuticals, cosmetics, and foods.

Important Regulatory Note: The food regulatory status of resveratrol in China remains in development. In 2014, resveratrol was accepted as a new food additive variety (Application No. (2014)0012). To date, resveratrol has not been included in the food additive list of GB 2760 "National Food Safety Standard – Standard for the Use of Food Additives" nor approved as a new food ingredient. Relevant companies are actively advancing food regulatory applications for resveratrol. In the EU, trans-resveratrol has been approved for use in food supplements. In the US, resveratrol is used as a dietary supplement ingredient and has obtained GRAS (Generally Recognized as Safe) status from the FDA. The food application sections of this report are primarily oriented toward international markets; domestic customers should verify the latest regulatory status before use.

Resveratrol can be divided into the following main varieties by product source and purity grade: Series