Cordyceps sinensis/militaris Extract là gì? Ứng dụng, liều dùng, sản phẩm thay thế & thông số

Cordyceps Sinensis Extract is a powdered or extract-like product processed from the dried composite of the stroma of Cordyceps sinensis (Berk.) Sacc. (a fungus of the Clavicipitaceae family) parasitic on the larvae of insects of the Hepialidae family, or from its artificially fermented mycelium, through processes including extraction, separation, purification, and drying. It is a deep-processed product of a valuable traditional Chinese medicinal material with multiple biological activities. Cordyceps sinensis, along with ginseng and deer antler, is known as one of the “Three Major Tonic Herbs of Traditional Chinese Medicine,” holding an extremely high medicinal value and tonic status. It is composed of two parts—the “worm” (the dead larva of a ghost moth) and the “grass” (the stroma of the Cordyceps fungus)—with the unique growth characteristic of being a “worm in winter and grass in summer.” It is primarily distributed in high-altitude regions including Qinghai, Tibet, Sichuan, Yunnan, and Gansu provinces. With the increasing scarcity of natural Cordyceps resources, fermented mycelium powder and its extracts have become mainstream products in the market. The main active components of Cordyceps sinensis extract include nucleosides (cordycepin, adenosine, uridine, guanosine, etc.), polysaccharides (cordyceps polysaccharides), sterols (ergosterol), amino acids (18 free amino acids, totaling 20%–25%), mannitol (cordycepic acid), and various trace elements. Among these, cordycepin and adenosine are the hallmark nucleoside components. Cordycepin has the function of inhibiting tumor cell proliferation and regulating immune function, while adenosine participates in energy metabolism and has protective effects on the cardiovascular system. Cordyceps sinensis extract appears as a brown-yellow to dark brown fine powder with a characteristic aroma and a slightly bitter taste. It has good water solubility and is available in various specifications including ratio extracts, cordycepin monomers, and cordyceps polysaccharides according to different application requirements.

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The raw materials for Cordyceps sinensis extract come from three main sources: natural wild Cordyceps sinensis fruiting bodies, artificially cultivated Cordyceps sinensis fruiting bodies, and Cordyceps sinensis mycelium obtained through submerged fermentation. Natural Cordyceps sinensis is primarily distributed in the high-altitude regions of the Qinghai-Tibet Plateau, including Qinghai, Tibet, Sichuan, Yunnan, and Gansu provinces. Due to the extreme scarcity and high cost of natural resources, most Cordyceps sinensis extracts on the market currently use artificially fermented mycelium as raw material. The anamorph (asexual stage) of Cordyceps sinensis is Hirsutella sinensis. Mycelium obtained through submerged fermentation has stable yields, controllable costs, and low risks of heavy metal and microbial contamination.