What Is Fumonisin-Degrading Enzyme (FumD Carboxylesterase / Fumzyme), Feed Mycotoxin Detoxifier? Applications, Dosage, Alternatives & Specifications

Fumonisin Degrading Enzyme is a class of bio-enzyme preparations that can specifically convert fumonisins (FUM) in feed and food into low-toxicity or non-toxic products. Fumonisins are water-soluble secondary metabolites produced by Fusarium fungi such as Fusarium verticillioides and Fusarium proliferatum. To date, 28 fumonisin analogues have been identified, classified into four series: A, B, C, and P, among which FB1 is the most widespread and toxic contaminant. Fumonisin Degrading Enzymes primarily belong to the esterase class (EC 3.1.1.87). Their mechanism of action involves a two-step enzymatic reaction for complete detoxification of fumonisins: first, under the action of carboxylesterase, fumonisin B1 (FB1) is degraded to hydrolyzed fumonisin B1 (HFB1), with significantly reduced toxicity; subsequently, under the action of aminotransferase, HFB1 undergoes transamination to ultimately convert to 2-keto-HFB1. This synergistic "esterase + aminotransferase" mechanism ensures complete degradation of fumonisins into non-toxic metabolites. Fumonisins are the second most prevalent group of mycotoxins worldwide. Since 2014, fumonisins have been detected in 50% to 80% of US corn samples. Monitoring data from 2025 shows that fumonisin detection rates in China and Taiwan reached 99%, exceeding risk thresholds. As a feed additive, the core function of Fumonisin Degrading Enzyme is to degrade fumonisins in the animal digestive tract into non-toxic products, protecting animal health. The world's first commercial fumonisin degrading enzyme product is FUMzyme® (developed by BIOMIN, a DSM-Firmenich company), which is the first FDA-approved purified enzyme to specifically and irreversibly degrade fumonisins into non-toxic metabolites. This product has received regulatory approvals from major markets including the EU, US FDA, and Canadian CFIA.

Fumonisin Degrading Enzyme can be divided into the following main varieties by enzyme source, mechanism of action, and application field: Series

Fumonisin Degrading Enzyme occupies a unique position in the global mycotoxin detoxifier market characterized by "specificity, efficiency, irreversibility, and no secondary pollution." Its core advantages include: